Genetic and biochemical analysis of the Hel308 Helicase in the Archaeon Haloferax volcanii
Hel308 is a monomeric 3’ to 5’ DNA helicase conserved throughout archaea and metazoans, but is absent from bacteria and fungi. Hel308 acts analogously to RecQ-family helicases, which serve as guardians of genome stability. Hel308 has been implicated in a variety of overlapping DNA repair pathways, i...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2020
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| Online Access: | https://eprints.nottingham.ac.uk/60024/ |