Development of three-dimensional spheroid models for the analysis of medulloblastoma drug response and metastatic dissemination

QR Code

Development of three-dimensional spheroid models for the analysis of medulloblastoma drug response and metastatic dissemination

Introduction: Medulloblastoma, the most common malignant paediatric brain tumour, is a heterogeneous disease with tumours classified based on their histological and molecular profiles. Studying medulloblastoma in vitro is challenging, as traditional two-dimensional (2D) cell culture models fail to r...

Full description

Bibliographic Details
Main Author:	Roper, Sophie Jayne
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	Medulloblastoma 3D In vitro Spheroid Drug response Metastatic dissemination
Online Access:	https://eprints.nottingham.ac.uk/59904/

Similar Items

Assessment of drug-loaded nanoparticles in a 3D in vitro brain tumour model
by: Ivanov, Delyan Pavlov
Published: (2015)

An investigation of metastatic markers in models of paediatric medulloblastoma
by: Nasir, Aishah
Published: (2017)

3D spheroid models for in vitro evaluation of nanoparticles for cancer therapy
by: Tchoryk, Aleksandra
Published: (2018)

Investigating the role of ascorbic acid and its transporters in medulloblastoma
by: Jones, Manon
Published: (2025)

Identifying factors that control medulloblastoma cell migration using a model of brain-CSF dissemination
by: Aldighieri, Macha
Published: (2020)

Development of a magnetic resonance imaging biomarker to improve prognostication in metastatic medulloblastoma
by: Mitoko, Christine Angeline
Published: (2021)

Investigating the role of Y-box binding protein 1 in medulloblastoma tumour progression and drug resistance
by: Taylor, Louisa
Published: (2022)

Investigating the role of exosomes in medulloblastoma and their involvement in metastasis
by: Jackson, Hannah Kate
Published: (2017)

The impact of medulloblastoma-derived extracellular vesicles on the development of primary cortical neurones
by: McCann, Sophie
Published: (2024)

Role of 8-Oxoguanine and its repair mechanisms in paediatric medulloblastoma
by: Imani, Katheeja
Published: (2023)

Investigating the role of TWIST1 in medulloblastoma metastasis
by: Cardall, Alice
Published: (2021)

Investigating the role of Rab GTPases in medulloblastoma pathogenesis
by: Entwistle, Susannah J.
Published: (2024)

Analysing the role of medulloblastoma exosomes as biomarkers and their functional contribution to metastasis
by: Jackson, Hannah K.
Published: (2021)

Molecular characterisation of the early metastatic phenotype in colorectal cancer
by: Sculthorpe, Declan
Published: (2024)

Exploring the role of multidrug exporters and extracellular vesicles in medulloblastoma chemoresistance
by: Wade, Philippa
Published: (2024)

The use of internet applications for the dissemination of knowledge for career management
by: Lloyd, Brenda
Published: (2012)

Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression
by: Gakhar, H., et al.
Published: (2015)

Investigating the role of tumour-deposited extracellular matrix in medulloblastoma progression
by: Johnson, James E. C.
Published: (2023)

Investigation the role of CD24 in metastatic colorectal cancer
by: Alsulaiman, Abdullah
Published: (2018)

The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis
by: Wong, C., et al.
Published: (2012)

Medulloblastoma and ependymoma cells display levels of 5-carboxylcytosine and elevated TET1 expression
by: Ramsawhook, Ashley, et al.
Published: (2017)

Outcome and health-related quality of life in patients undergoing surgery for spinal metastases and metastatic spinal cord compression
by: Quraishi, Nasir A.
Published: (2020)

What influences the dissemination of online rumour messages in social media: the role of message, communicator, channel and rumour features
by: Li, Boying
Published: (2019)

Lobsters: the search for knowledge continues (and why we need to know!)
by: Phillips, Bruce
Published: (2005)

The Roles Performed by Consultants in Disseminating EMA in Philippines and the Need for New Approaches to Implement EMA
by: Ghosh, Biswaraj
Published: (2012)

Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh
by: Mohd Salleh, Nurul Hidayah
Published: (2015)

Impact of psychological stress and mammary tumour growth on structural and functional protein expression in cognitive brain areas
by: Alzboon, Walla'
Published: (2025)

Integration of an in vitro renal cellular set of tools with systems biology modelling to predict the renal contribution to the pharmacokinetics of a drug
by: Taylor, Patrick
Published: (2020)

Curriculum dissemination in TAFE : a study of the educational change process in the Technical and Further Education sector in Western Australia
by: McBeath, Ursula Clare
Published: (1994)

Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours
by: Nailor, Audrey, et al.
Published: (2016)

Three Dimensional Printed Immunomodulatory Scaffolds with Controlled Drug Release for Bone Regeneration
by: Majrashi, Majed
Published: (2023)

Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery
by: Louzao, Iria, et al.
Published: (2018)

High-throughput spheroid screens using volume, resazurin reduction and acid phosphatase activity
by: Ivanov, Delyan Pavlov, et al.
Published: (2017)

Ipratropium is ‘luminally recycled’ by an inter-play between apical uptake and efflux transporters in Calu-3 bronchial epithelial cell layers
by: Panduga, Vijender, et al.
Published: (2017)

Resultant optimization of the three-dimensional intersection problem
by: Awange, Joseph, et al.
Published: (2007)

Design and fabrication of a device for three-dimensional neuronal development
by: Gonçalves Lobato de Almeida, Maria Teresa
Published: (2021)

Implementing 3D Printing for the Long-Term Release of Biomacromolecules
by: Plender, Kristian
Published: (2023)

In Vitro Fertilization Of Hamster Ova As An Aid In Assessing The Fertilizing Capacity Of Human Spermatozoa
by: Syed Mohamed, Syed zulkifli
Published: (1986)

Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin
by: Mohamad Zin, Nur Zahirah
Published: (2015)

Transplanting Tissa: "New Voices" in Trans-Tasman Social Work Research
by: Watts, Lynelle, et al.
Published: (2024)