(E)-Vinylphosphonates: nuclease-stable phosphate mimics for effective single-stranded RNA gene silencing

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(E)-Vinylphosphonates: nuclease-stable phosphate mimics for effective single-stranded RNA gene silencing

The therapeutic efficacy of double-stranded short interfering RNAs (ds-siRNAs) is limited by the formation of the lipid complex to deliver them to cells. Whereas if effective single-stranded siRNAs (ss-siRNAs) could be developed, they would offer an easier way of delivery and they can be produced at...

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Bibliographic Details
Main Author:	Al-Kadhimi, Mustafa M.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	ss-siRNA; Vinylphosphonates; Oligonucleotide
Online Access:	https://eprints.nottingham.ac.uk/59566/

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