(E)-Vinylphosphonates: nuclease-stable phosphate mimics for effective single-stranded RNA gene silencing
The therapeutic efficacy of double-stranded short interfering RNAs (ds-siRNAs) is limited by the formation of the lipid complex to deliver them to cells. Whereas if effective single-stranded siRNAs (ss-siRNAs) could be developed, they would offer an easier way of delivery and they can be produced at...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2020
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| Online Access: | https://eprints.nottingham.ac.uk/59566/ |