Improving the maturation of human pluripotent stem cell - derived hepatocyte-like cells using an automated-design of experiments approach

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Improving the maturation of human pluripotent stem cell - derived hepatocyte-like cells using an automated-design of experiments approach

Human primary hepatocytes (pHEPs) are used as the gold standard model for drug screening and toxicity testing in the drug development pipeline. However, the rapid post isolation changes in cell structure, morphology, gene expression and metabolic activity, together with donor availability and hetero...

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Bibliographic Details
Main Author:	Fotopoulos, Lazaros
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	HLC Hepatocytes Stem cells Maturation Stem cell ipsc Liver Enzymes Functionality doe Design of experiments Automation Robotics Development Human
Online Access:	https://eprints.nottingham.ac.uk/56775/

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