Improving the maturation of human pluripotent stem cell - derived hepatocyte-like cells using an automated-design of experiments approach
Human primary hepatocytes (pHEPs) are used as the gold standard model for drug screening and toxicity testing in the drug development pipeline. However, the rapid post isolation changes in cell structure, morphology, gene expression and metabolic activity, together with donor availability and hetero...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2019
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| Online Access: | https://eprints.nottingham.ac.uk/56775/ |