1-Hydroxy-xanthine Inhibitors of Caf1 Deadenylase as a Potential Treatment for Osteoporosis

QR Code

1-Hydroxy-xanthine Inhibitors of Caf1 Deadenylase as a Potential Treatment for Osteoporosis

Caf1 is a subunit of the CCR4-NOT complex. The role of Caf1 is that of a magnesium dependent deadenylase enzyme, which removes the poly(A) tail of mRNA (deadenylation). The degradation of the poly(A) tail has a downstream effect on mRNA translation and subsequent protein synthesis. Caf1 is implicate...

Full description

Bibliographic Details
Main Author:	Ziemann, Max
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	Medicinal chemistry organic chemistry drug discovery nuclease deadenylase Caf1 pop2 inhibitor xanthine 1-hydroxy xanthine 1-hydroxy purine-2 6-dione
Online Access:	https://eprints.nottingham.ac.uk/56154/

Similar Items

A nonenzymatic sensor for xanthine based on electrospun carbon nanofibers modified electrode
by: Tang, X., et al.
Published: (2011)

Antinociceptive profile of a synthetic curcuminoid derivative, 2,6-bis-4-(hydroxy-3-methoxy-benzilidine)-cyclohexanone in murine model of induced-nociception
by: Lee, Ming Tatt
Published: (2013)

Resistance mechanism of Limnocharis flava (L.) Buchenau to acetohydroxy acid synthase inhibitors
by: Zakaria, Norazua
Published: (2018)

Investigation of the PABPC1-BTG2 interaction and its effects on mRNA deadenylation by CNOT7(CAF1)
by: Ameerul Moominin, Aalam Mohammed
Published: (2022)

Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism
by: Wilkinson, Daniel J., et al.
Published: (2017)

Natural products as novel reagents for the detection of latent fingermarks
by: Jelly, Renee Michelle
Published: (2010)

Biochemical analysis of the BTG1 variants associated with Non-Hodgkin’s lymphoma
by: Almasmoum, Hibah
Published: (2017)

Molecular analysis of the Ccr4-Not deadenylase: relevance to human disease
by: Airhihen, Blessing
Published: (2017)

Novel multifunctional of magnesium ions (Mg++) incorporated calcium phosphate nanostructures
by: Thanigai Arul, K., et al.
Published: (2018)

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module
by: Maryati, Marayti, et al.
Published: (2015)

Effects of NAD at purine receptors in isolated blood vessels
by: Alefishat, Eman, et al.
Published: (2015)

Cas3 nuclease activity is regulated by an iHDA1 region located at the interface between HD and RecA1 domain
by: He, Liu
Published: (2022)

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes
by: Doidge, Rachel L.
Published: (2013)

4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity
by: Lim, Felicia Phei Lin, et al.
Published: (2014)

1-[(E)-(3-Hydroxy-4-methoxybenzylidene)amino]- 3-methylthiourea
by: Arafath, Md. Azharul, et al.
Published: (2016)

4-Hydroxy-3-methoxybenzaldehyde-nicotinamide (1/1)
by: How, Fiona Ni Foong, et al.
Published: (2011)

1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry
by: Lim, Felicia Phei Lin, et al.
Published: (2014)

A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines
by: Kalinina, S., et al.
Published: (2013)

P2X purinergic receptor ligands: recently patented compounds
by: Gunosewoyo, Hendra, et al.
Published: (2010)

Physicochemical and electrochemical properties of 1,1,2,2‐tetrafluoroethyl‐2,2,3,3‐tetrafluoropropyl ether as a co‐solvent for high‐voltage lithium‐ion electrolytes
by: Xia, Lan, et al.
Published: (2019)

Benthic macroinvertebrate assemblages in remediated wetlands around Sydney, Australia
by: Rawson, Christopher, et al.
Published: (2010)

The role of relaxin family receptor 1 and 2 (RXFP1 and RXFP2) in gender- specific physiology and pathology
by: Alhujaili, Waleed
Published: (2021)

2-[1-(2-hydroxy-3-methoxybenzyl)-1H-benzimidazol-2-yl]-6-methoxyphenol monohydrate
by: Al-Douh, Mohammed Hadi, et al.
Published: (2009)

2-[1-(2-Hydroxy-3-methoxybenzyl)-1H-benzimidazol-2-yl]-6-methoxyphenol methanol 1.13-solvate
by: Al-Douh, Mohammed H., et al.
Published: (2009)

CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation
by: Quintero, Cynthia M., et al.
Published: (2018)

Truth, good and beauty: the politics of celebrity in China
by: Sullivan, Jonathan, et al.
Published: (2017)

A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation
by: Lim, Felicia Phei Lin, et al.
Published: (2014)

Crystal structure and Hirshfeld surface analysis of 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium 2-hydroxy-2-phenylacetate hemihydrate
by: Wardell, James L., et al.
Published: (2016)

Annexin A2 antibodies but not inhibitors of the annexin A2 heterotetramer impair productive HIV-1 infection of macrophages in vitro
by: Woodham, Andrew W., et al.
Published: (2016)

4-Benzyloxy-1,1'-biphenyl
by: Adam, Farook, et al.
Published: (2016)

Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid
by: Kaliszczak, M., et al.
Published: (2022)

Gathering Psychometric Evidence for ASCIv2 to Support Cross-Cultural Attitudinal Studies for College Chemistry Programs
by: Southam, Daniel, et al.
Published: (2014)

Nutritional and functional properties of popped chickpea and red kidney bean
by: Godrich, Joseph
Published: (2024)

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling
by: Goode, Alice, et al.
Published: (2016)

Inhibition of HER2 enriches for Jagged1-dependent breast cancer stem cells: role for membrane Jagged1
by: Shah, Deep, et al.
Published: (2018)

1-[5-(2-Chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro- 1H-pyrazol-1-yl]ethan-1-one
by: Adam, Farook, et al.
Published: (2016)

{4-Hydroxy-N'-[(2-oxido-1-naphthyl-O) methylidene] benzohydrazidato-2N', O} dimethyltin (IV)
by: Fasihuddin B, Ahmad, et al.
Published: (2010)

DNA methylation analysis of Sox2 regulatory regions SRR1 and SRR2 in undifferentiated and differentiated mouse embryonic stem cells
by: Batool, Sajida
Published: (2013)

Analysis of g s-transferase, protien tyrosine phosphatase 1B, nuclear factor kappa-B1 and leptin receptor genetic polymorphisms as risk factors for Malaysian type 2 diabetes mellitus subjects
by: Etemad, Ali
Published: (2013)

Crystal structure of 1-{3-(4-methylphenyl)-5-[(E)-2-phenylethenyl]-4,5-dihydro-1H-pyrazol-1-yl}ethan-1-one
by: Adam, Farook, et al.
Published: (2015)