1-Hydroxy-xanthine Inhibitors of Caf1 Deadenylase as a Potential Treatment for Osteoporosis
Caf1 is a subunit of the CCR4-NOT complex. The role of Caf1 is that of a magnesium dependent deadenylase enzyme, which removes the poly(A) tail of mRNA (deadenylation). The degradation of the poly(A) tail has a downstream effect on mRNA translation and subsequent protein synthesis. Caf1 is implicate...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2019
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| Online Access: | https://eprints.nottingham.ac.uk/56154/ |