Investigation of CRISPR-Cas adaptation mechanism through exploration of Cas4-1 fusions
CRISPR-Cas is an adaptive immune system present in bacteria and archaea. It involves two linked stages: adaptation and interference. Adaptation generates a database of mobile genetic element sequences within a CRISPR locus through ‘capture’ of DNA fragments by Cas1-Cas2 and integration into the CRIS...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2019
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| Online Access: | https://eprints.nottingham.ac.uk/56071/ |