Metabolic regulation and consequences of an altered microenvironment in cancer cell lines

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Metabolic regulation and consequences of an altered microenvironment in cancer cell lines

Tumours are commonly associated with a shift in cellular metabolism to establish an acidic microenvironment that is further exacerbated by hypoxia. Such changes in extracellular pH (pHe) and oxygen tension (PO2) alter ion homeostasis effecting cancer hallmarks. High intracellular potassium (K+) is a...

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Bibliographic Details
Main Author:	Bose, Ujjal
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	Microenvironment Intracellular pH Hypoxia TASK-3 Proliferation Acid extrusion
Online Access:	https://eprints.nottingham.ac.uk/55919/

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