Investigating bisubstrate inhibitors of PRMT1 and CARM1

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Investigating bisubstrate inhibitors of PRMT1 and CARM1

Protein arginine methyltransferases (PRMTs) are gaining traction as a novel drug target class for a wide range of diseases. The high sequence conservation within the active sites of the nine human PRMTs, particularly in the co-factor (S-adenosyl methionine [SAM]) binding site, makes the design of is...

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Bibliographic Details
Main Author:	Gunnell, Emma
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	Protein arginine methyltransferases; Linker-length effects; PRMT inhibitors; Bisubstrate SAM inhibitor scaffold; Binding
Online Access:	https://eprints.nottingham.ac.uk/55868/

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