Investigating bisubstrate inhibitors of PRMT1 and CARM1
Protein arginine methyltransferases (PRMTs) are gaining traction as a novel drug target class for a wide range of diseases. The high sequence conservation within the active sites of the nine human PRMTs, particularly in the co-factor (S-adenosyl methionine [SAM]) binding site, makes the design of is...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2019
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| Online Access: | https://eprints.nottingham.ac.uk/55868/ |