Investigating a key autophagy protein-protein interaction and its modulation by phosphorylation and an ALS-related mutation

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Investigating a key autophagy protein-protein interaction and its modulation by phosphorylation and an ALS-related mutation

Autophagy is a cellular degradation pathway which removes cytoplasmic material including protein aggregates, damaged organelles and pathogens. The interaction of the autophagy adaptor p62 with lipid-anchored hAtg8 receptor proteins is a key step in this process whereby cargo bound to p62 is sequeste...

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Bibliographic Details
Main Author:	Brennan, Andrew
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	Autophagy; Protein-protein interaction; hAtg8 proteins; Binding interactions; Phosphorylation
Online Access:	https://eprints.nottingham.ac.uk/55747/

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