Attenuated post-movement beta rebound associated with schizotypal features in healthy people
Introduction: Schizophrenia and Schizotypal Personality Disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the two conditions. However, schizotypy is a heterogeneous facet of personality in the healthy population and so may be s...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2018
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| Online Access: | https://eprints.nottingham.ac.uk/53812/ |
| _version_ | 1848798989294501888 |
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| author | Benjamin A.E., Hunt Elizabeth B., Liddle Lauren E., Gascoyne Lorenzo, Magazzini Bethany C., Routley Krish D., Singh Peter G., Morris Matthew J., Brookes Peter F., Liddle |
| author_facet | Benjamin A.E., Hunt Elizabeth B., Liddle Lauren E., Gascoyne Lorenzo, Magazzini Bethany C., Routley Krish D., Singh Peter G., Morris Matthew J., Brookes Peter F., Liddle |
| author_sort | Benjamin A.E., Hunt |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Introduction: Schizophrenia and Schizotypal Personality Disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the two conditions. However, schizotypy is a heterogeneous facet of personality in the healthy population and so may be seen as a bridge between health and mental illness. Neural evidence for such a continuity would have implications for the characterization and treatment of schizophrenia. Based on our previous work identifying a relationship between symptomology in Schizophrenia and abnormal movement-induced electrophysiological response (the post-movement beta rebound (PMBR)), we predicted that if subclinical schizotypy arises from similar neural mechanisms to schizophrenia, schizotypy in healthy individuals would be associated with reduced PMBR.
Methods: 116 participants completed a visuomotor task whilst their neural activity was recorded by magnetoencephalography. Partial correlations were computed between a measure of PMBR extracted from left primary motor cortex and scores on the Schizotypal Personality Questionnaire (SPQ), a self-report measure of schizotypal personality. Correlations between PMBR and SPQ factor scores measuring Cognitive-Perceptual, Interpersonal and Disorganization dimensions of schizotypy were also computed. Effects of site, age, and sex were controlled for.
Results: We found a significant negative correlation between total SPQ score and PMBR. This was most strongly mediated by variance shared between Interpersonal and Disorganization factor scores.
Conclusion: These findings indicate a continuum of neural deficit between schizotypy and schizophrenia, with diminution of PMBR, previously reported in schizophrenia, also measurable in individuals with schizotypal features, particularly disorganization and impaired interpersonal relations. |
| first_indexed | 2025-11-14T20:28:32Z |
| format | Article |
| id | nottingham-53812 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:28:32Z |
| publishDate | 2018 |
| publisher | Oxford University Press |
| recordtype | eprints |
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| spelling | nottingham-538122018-09-21T09:27:32Z https://eprints.nottingham.ac.uk/53812/ Attenuated post-movement beta rebound associated with schizotypal features in healthy people Benjamin A.E., Hunt Elizabeth B., Liddle Lauren E., Gascoyne Lorenzo, Magazzini Bethany C., Routley Krish D., Singh Peter G., Morris Matthew J., Brookes Peter F., Liddle Introduction: Schizophrenia and Schizotypal Personality Disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the two conditions. However, schizotypy is a heterogeneous facet of personality in the healthy population and so may be seen as a bridge between health and mental illness. Neural evidence for such a continuity would have implications for the characterization and treatment of schizophrenia. Based on our previous work identifying a relationship between symptomology in Schizophrenia and abnormal movement-induced electrophysiological response (the post-movement beta rebound (PMBR)), we predicted that if subclinical schizotypy arises from similar neural mechanisms to schizophrenia, schizotypy in healthy individuals would be associated with reduced PMBR. Methods: 116 participants completed a visuomotor task whilst their neural activity was recorded by magnetoencephalography. Partial correlations were computed between a measure of PMBR extracted from left primary motor cortex and scores on the Schizotypal Personality Questionnaire (SPQ), a self-report measure of schizotypal personality. Correlations between PMBR and SPQ factor scores measuring Cognitive-Perceptual, Interpersonal and Disorganization dimensions of schizotypy were also computed. Effects of site, age, and sex were controlled for. Results: We found a significant negative correlation between total SPQ score and PMBR. This was most strongly mediated by variance shared between Interpersonal and Disorganization factor scores. Conclusion: These findings indicate a continuum of neural deficit between schizotypy and schizophrenia, with diminution of PMBR, previously reported in schizophrenia, also measurable in individuals with schizotypal features, particularly disorganization and impaired interpersonal relations. Oxford University Press 2018-09-18 Article PeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/53812/7/sby117.pdf Benjamin A.E., Hunt, Elizabeth B., Liddle, Lauren E., Gascoyne, Lorenzo, Magazzini, Bethany C., Routley, Krish D., Singh, Peter G., Morris, Matthew J., Brookes and Peter F., Liddle (2018) Attenuated post-movement beta rebound associated with schizotypal features in healthy people. Schizophrenia Bulletin . ISSN 1745-1701 Magnetoencephalography; Schizotypy; Schizophrenia; Individual Differences; Schizotypal Personality Disorder; Psychosis https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sby117/5095481?rss=1 doi:10.1093/schbul/sby117 doi:10.1093/schbul/sby117 |
| spellingShingle | Magnetoencephalography; Schizotypy; Schizophrenia; Individual Differences; Schizotypal Personality Disorder; Psychosis Benjamin A.E., Hunt Elizabeth B., Liddle Lauren E., Gascoyne Lorenzo, Magazzini Bethany C., Routley Krish D., Singh Peter G., Morris Matthew J., Brookes Peter F., Liddle Attenuated post-movement beta rebound associated with schizotypal features in healthy people |
| title | Attenuated post-movement beta rebound associated with schizotypal features in healthy people |
| title_full | Attenuated post-movement beta rebound associated with schizotypal features in healthy people |
| title_fullStr | Attenuated post-movement beta rebound associated with schizotypal features in healthy people |
| title_full_unstemmed | Attenuated post-movement beta rebound associated with schizotypal features in healthy people |
| title_short | Attenuated post-movement beta rebound associated with schizotypal features in healthy people |
| title_sort | attenuated post-movement beta rebound associated with schizotypal features in healthy people |
| topic | Magnetoencephalography; Schizotypy; Schizophrenia; Individual Differences; Schizotypal Personality Disorder; Psychosis |
| url | https://eprints.nottingham.ac.uk/53812/ https://eprints.nottingham.ac.uk/53812/ https://eprints.nottingham.ac.uk/53812/ |