CRISPR-Cas9 gene targeting of human induced pluripotent stem cells to generate a palette of optical reporter cell lines towards investigating hypertrophic cardiomyopathy

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CRISPR-Cas9 gene targeting of human induced pluripotent stem cells to generate a palette of optical reporter cell lines towards investigating hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is an inherited cardiomyopathy with a variety of causative mutations, largely within sarcomeric proteins. This can result in thickening of the left ventricle of the heart, altered contractility, arrhythmias, and in some cases, sudden cardiac death. Human induce...

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Bibliographic Details
Main Author:	Bhagwan, Jamie R.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2018
Subjects:	Hypertrophic cardiomyopathy; CRISPR-Cas9; In vitro study; Mutations
Online Access:	https://eprints.nottingham.ac.uk/53554/

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