CRISPR-Cas9 gene targeting of human induced pluripotent stem cells to generate a palette of optical reporter cell lines towards investigating hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is an inherited cardiomyopathy with a variety of causative mutations, largely within sarcomeric proteins. This can result in thickening of the left ventricle of the heart, altered contractility, arrhythmias, and in some cases, sudden cardiac death. Human induce...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2018
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| Online Access: | https://eprints.nottingham.ac.uk/53554/ |