Assessment of an in silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative

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Assessment of an in silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative

International Council on Harmonization S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are proarrhythmic. In response, the Comprehensive In Vitro Proarrhythmia Assay (CiPA) was proposed that integrates multi-ion channel pharmacology data in vitro into a hu...

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Bibliographic Details
Main Authors:	Li, Zhihua, Wu, Wendy W., Sheng, Jiansong, Tran, Phu N., Wu, Min, Ranolph, Aaron, Johnstone, Ross H., Mirams, Gary R., Kuryshev, Yuri, Kramer, James, Wu, Caiyun, Crumb, William J., Strauss, David G.
Format:	Article
Published:	American Society for Clinical Pharmacology and Therapeutics 2018
Online Access:	https://eprints.nottingham.ac.uk/53210/

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