Assessment of an in silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative
International Council on Harmonization S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are proarrhythmic. In response, the Comprehensive In Vitro Proarrhythmia Assay (CiPA) was proposed that integrates multi-ion channel pharmacology data in vitro into a hu...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Published: |
American Society for Clinical Pharmacology and Therapeutics
2018
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| Online Access: | https://eprints.nottingham.ac.uk/53210/ |