Sensory neuronal sensitisation occurs through HMGB-1/RAGE and TRPV1 in high glucose conditions

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Sensory neuronal sensitisation occurs through HMGB-1/RAGE and TRPV1 in high glucose conditions

Many potential causes for painful diabetic neuropathy have been proposed including actions of cytokines and growth factors. High mobility group protein B1 (HMGB1) is a RAGE agonist, increased in diabetes, that contributes to pain by modulating peripheral inflammatory responses. HMGB1 enhances nocice...

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Bibliographic Details
Main Authors:	Bestall, S.M., Hulse, R.P., Blackley, Z., Swift, M., Ved, N., Paton, K., Beazley-Long, N., Bates, D.O., Donaldson, L.F.
Format:	Article
Published:	Company of Biologists 2018
Subjects:	HMGB1; RAGE; Nociceptor; Sensitization
Online Access:	https://eprints.nottingham.ac.uk/53133/

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