Sensory neuronal sensitisation occurs through HMGB-1/RAGE and TRPV1 in high glucose conditions
Many potential causes for painful diabetic neuropathy have been proposed including actions of cytokines and growth factors. High mobility group protein B1 (HMGB1) is a RAGE agonist, increased in diabetes, that contributes to pain by modulating peripheral inflammatory responses. HMGB1 enhances nocice...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Published: |
Company of Biologists
2018
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/53133/ |