Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles
A gold(I) N-heterocyclic carbene 4 from a bis-imidazolium-amphiphile was synthesized and characterized. The cytotoxicity against HT-29 colon carcinoma and MDA-MB-231 breast adenocarcinoma cells was assessed for the NHC complex 4, the imidazolium salt precursor 2, and its methyl analogue 3, indicatin...
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| Format: | Article |
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Royal Society of Chemistry
2015
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| Online Access: | https://eprints.nottingham.ac.uk/52915/ |
| _version_ | 1848798839332405248 |
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| author | Rodrigues, Mafalda Russo, Lorenzo Aguilo, E. Rodriguez, L. Ott, I. Pérez-García, Lluïsa |
| author_facet | Rodrigues, Mafalda Russo, Lorenzo Aguilo, E. Rodriguez, L. Ott, I. Pérez-García, Lluïsa |
| author_sort | Rodrigues, Mafalda |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A gold(I) N-heterocyclic carbene 4 from a bis-imidazolium-amphiphile was synthesized and characterized. The cytotoxicity against HT-29 colon carcinoma and MDA-MB-231 breast adenocarcinoma cells was assessed for the NHC complex 4, the imidazolium salt precursor 2, and its methyl analogue 3, indicating that compounds 2–4 are promising cytotoxic agents. Furthermore, the ability of these compounds to be associated with gold nanoparticles was also explored, in order to develop an anticancer drug delivery system. The free ligands displayed more activity when compared with the ligands immobilized on the gold nanoparticles. The synthesized gold particles incorporating the bis-imidazolium salts either 2 or 3 showed monodisperse spherical shape with sizes of approximately 5 nm. |
| first_indexed | 2025-11-14T20:26:09Z |
| format | Article |
| id | nottingham-52915 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:26:09Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-529152020-05-04T17:26:04Z https://eprints.nottingham.ac.uk/52915/ Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles Rodrigues, Mafalda Russo, Lorenzo Aguilo, E. Rodriguez, L. Ott, I. Pérez-García, Lluïsa A gold(I) N-heterocyclic carbene 4 from a bis-imidazolium-amphiphile was synthesized and characterized. The cytotoxicity against HT-29 colon carcinoma and MDA-MB-231 breast adenocarcinoma cells was assessed for the NHC complex 4, the imidazolium salt precursor 2, and its methyl analogue 3, indicating that compounds 2–4 are promising cytotoxic agents. Furthermore, the ability of these compounds to be associated with gold nanoparticles was also explored, in order to develop an anticancer drug delivery system. The free ligands displayed more activity when compared with the ligands immobilized on the gold nanoparticles. The synthesized gold particles incorporating the bis-imidazolium salts either 2 or 3 showed monodisperse spherical shape with sizes of approximately 5 nm. Royal Society of Chemistry 2015-12-22 Article PeerReviewed Rodrigues, Mafalda, Russo, Lorenzo, Aguilo, E., Rodriguez, L., Ott, I. and Pérez-García, Lluïsa (2015) Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles. RSC Advances, 6 . pp. 2202-2209. ISSN 2046-2069 http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA21621D#!divAbstract doi:10.1039/C5RA21621D doi:10.1039/C5RA21621D |
| spellingShingle | Rodrigues, Mafalda Russo, Lorenzo Aguilo, E. Rodriguez, L. Ott, I. Pérez-García, Lluïsa Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles |
| title | Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles |
| title_full | Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles |
| title_fullStr | Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles |
| title_full_unstemmed | Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles |
| title_short | Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles |
| title_sort | au(i) n-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles |
| url | https://eprints.nottingham.ac.uk/52915/ https://eprints.nottingham.ac.uk/52915/ https://eprints.nottingham.ac.uk/52915/ |