Nitrogen-Bridged, Natural Product-Like Octahydrobenzofurans and Octahydroindoles: Scope and Mechanism of Bridge-Forming Reductive Amination via Caged Heteroadamantanes

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Nitrogen-Bridged, Natural Product-Like Octahydrobenzofurans and Octahydroindoles: Scope and Mechanism of Bridge-Forming Reductive Amination via Caged Heteroadamantanes

The biological significance of sp3-rich synthetic scaffolds with natural product-like features yet distinct global frameworks is being increasingly recognised in medicinal chemistry and biochemistry. Taking inspiration from the vast array of bioactive, bridged alkaloids, we report the synthesis of u...

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Bibliographic Details
Main Authors:	Wales, Steven M., Adcock, Holly V., Lewis, William, Hamza, Daniel, Moody, Christopher J.
Format:	Article
Published:	Wiley-VCH Verlag 2018
Subjects:	aza-Michael addition; bridged compounds; drug discovery; heterocycles; reductive amination
Online Access:	https://eprints.nottingham.ac.uk/52907/

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