Nitrogen-Bridged, Natural Product-Like Octahydrobenzofurans and Octahydroindoles: Scope and Mechanism of Bridge-Forming Reductive Amination via Caged Heteroadamantanes
The biological significance of sp3-rich synthetic scaffolds with natural product-like features yet distinct global frameworks is being increasingly recognised in medicinal chemistry and biochemistry. Taking inspiration from the vast array of bioactive, bridged alkaloids, we report the synthesis of u...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Wiley-VCH Verlag
2018
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/52907/ |