A fellowship of Ring1 maintains AML stem cells
Polycomb repressive complex 1 (PRC1) and PRC2 are transcriptional repressors that function as key regulators of the self-renewal and differentiation (cell lineage specification) pathways in stem cells. In this issue of Blood, Shima et al1 report that 2 ubiquitin ligases (Ring1A and Ring1B), which ar...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
American Society of Hematology
2018
|
| Online Access: | https://eprints.nottingham.ac.uk/52899/ |
| _version_ | 1848798835347816448 |
|---|---|
| author | Heery, David M. |
| author_facet | Heery, David M. |
| author_sort | Heery, David M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Polycomb repressive complex 1 (PRC1) and PRC2 are transcriptional repressors that function as key regulators of the self-renewal and differentiation (cell lineage specification) pathways in stem cells. In this issue of Blood, Shima et al1 report that 2 ubiquitin ligases (Ring1A and Ring1B), which are key components of PRC1 complexes, are essential for the establishment and maintenance of acute myeloid leukemia (AML) in mouse models. |
| first_indexed | 2025-11-14T20:26:05Z |
| format | Article |
| id | nottingham-52899 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T20:26:05Z |
| publishDate | 2018 |
| publisher | American Society of Hematology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-528992019-04-19T04:30:27Z https://eprints.nottingham.ac.uk/52899/ A fellowship of Ring1 maintains AML stem cells Heery, David M. Polycomb repressive complex 1 (PRC1) and PRC2 are transcriptional repressors that function as key regulators of the self-renewal and differentiation (cell lineage specification) pathways in stem cells. In this issue of Blood, Shima et al1 report that 2 ubiquitin ligases (Ring1A and Ring1B), which are key components of PRC1 complexes, are essential for the establishment and maintenance of acute myeloid leukemia (AML) in mouse models. American Society of Hematology 2018-04-19 Article PeerReviewed application/pdf en https://eprints.nottingham.ac.uk/52899/1/A%20Fellowship%20of%20RING%20Proteins%20in%20AML%20Stem%20Cells.pdf image/tiff en https://eprints.nottingham.ac.uk/52899/7/Figure_v2.tif Heery, David M. (2018) A fellowship of Ring1 maintains AML stem cells. Blood, 131 (16). pp. 1771-1773. ISSN 1528-0020 http://dx.doi.org/10.1182/blood-2018-02-832121 doi:10.1182/blood-2018-02-832121 doi:10.1182/blood-2018-02-832121 |
| spellingShingle | Heery, David M. A fellowship of Ring1 maintains AML stem cells |
| title | A fellowship of Ring1 maintains AML stem cells |
| title_full | A fellowship of Ring1 maintains AML stem cells |
| title_fullStr | A fellowship of Ring1 maintains AML stem cells |
| title_full_unstemmed | A fellowship of Ring1 maintains AML stem cells |
| title_short | A fellowship of Ring1 maintains AML stem cells |
| title_sort | fellowship of ring1 maintains aml stem cells |
| url | https://eprints.nottingham.ac.uk/52899/ https://eprints.nottingham.ac.uk/52899/ https://eprints.nottingham.ac.uk/52899/ |