The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response

Background: Cyclin-Dependent Kinases (CDKs) are established anti-cancer drug targets and a new generation of CDK inhibitors are providing clinical benefits to a sub-set of breast cancer patients. We have recently shown that human CDK18 promotes efficient cellular responses to replication stress. In...

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Bibliographic Details
Main Authors: Barone, Giancarlo, Arora, Arvind, Ganesh, Anil, Abdel-Fatah, Tarek, Moseley, Paul, Ali, Reem, Chan, Stephen Y.T., Savva, Constantinos, Schiavone, Kristina, Carmell, Natasha, Myers, Katie N., Rakha, Emad A., Madhusudan, Srinivasan, Collis, Spencer J.
Format: Article
Published: Impact Journals 2018
Subjects:
CDK18
breast cancer
replication stress
chemotherapy
cyclin-dependent kinase
CRISPR
Online Access:https://eprints.nottingham.ac.uk/52471/

Internet

https://eprints.nottingham.ac.uk/52471/

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