Inhibition of HER2 enriches for Jagged1-dependent breast cancer stem cells: role for membrane Jagged1

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Inhibition of HER2 enriches for Jagged1-dependent breast cancer stem cells: role for membrane Jagged1

Purpose: Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer is driven by cells possessing stem-like properties of self-renewal and differentiation, referred to as Cancer Stem Cells (CSCs). CSCs are implicated in radiotherapy, chemotherapy resistance, and tumor recurrence. Notch p...

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Bibliographic Details
Main Authors:	Shah, Deep, Wyatt, Debra, Baker, Andrew, Simms, Patricia, Peiffer, Daniel S., Fernandez, Michelle L., Rakha, Emad A., Green, Andrew R., Filipovic, Aleksandra, Miele, Lucio, Osipo, Clodia
Format:	Article
Published:	American Association for Cancer Research 2018
Subjects:	Breast Cancer HER2 Jagged1 Cancer Stem Cells
Online Access:	https://eprints.nottingham.ac.uk/52451/

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