Inhibition of HER2 enriches for Jagged1-dependent breast cancer stem cells: role for membrane Jagged1
Purpose: Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer is driven by cells possessing stem-like properties of self-renewal and differentiation, referred to as Cancer Stem Cells (CSCs). CSCs are implicated in radiotherapy, chemotherapy resistance, and tumor recurrence. Notch p...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Published: |
American Association for Cancer Research
2018
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/52451/ |