Evolution of pluripotency: hijacking of an ancient network

Pluripotency is conserved in the major trunk of Vertebrate evolution, but how the gene regulatory network (GRN) that governs it evolved is poorly understood. A central component of this network is the Homeodomain containing transcription factor Nanog. How Nanog evolved is not understood, as Nanog s...

Full description

Bibliographic Details
Main Author: Crowley, Darren Jerome
Format: Thesis (University of Nottingham only)
Language:English
Published: 2018
Online Access:https://eprints.nottingham.ac.uk/52197/