Biochemical characterisation of the human Ccr4-Not complex: core complex assembly and deadenylation activity

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Biochemical characterisation of the human Ccr4-Not complex: core complex assembly and deadenylation activity

Targeted degradation of cytoplasmic mRNA is of fundamental importance for regulated gene expression in eukaryotic cells. The shortening and removal of the poly(A) tail (deadenylation) is the initial and often rate-limiting step in this process. Two key components in deadenylation are the PAN2-PAN3 a...

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Bibliographic Details
Main Author:	Pavanello, Lorenzo
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2018
Online Access:	https://eprints.nottingham.ac.uk/52089/

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