Biochemical characterisation of the human Ccr4-Not complex: core complex assembly and deadenylation activity
Targeted degradation of cytoplasmic mRNA is of fundamental importance for regulated gene expression in eukaryotic cells. The shortening and removal of the poly(A) tail (deadenylation) is the initial and often rate-limiting step in this process. Two key components in deadenylation are the PAN2-PAN3 a...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52089/ |