DEF6 is associated with the translational initiation regulating protein synthesis of eIF4E, 4E-T and PABP and colocalises with eIF4E and PABP in the immunological synapse
DEF6 is an atypical guanine nucleotide exchange factor (GEF) for Rho GTPases Rac1 and Cdc42, which is highly expressed in mature T cells. DEF6 is recruited to the immunological synapse (IS) following phosphorylation by LCK in response to T cell receptor (TCR) stimulation during inflammation. In rest...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51984/ |