Pathway discovery using transcriptomic profiles in adult-onset severe asthma

QR Code

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

Background: Adult-onset severe asthma is characterized by highly symptomatic disease despite high-intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease is needed for the development of targeted treatments. Gene set variation analysis is a statistical tec...

Full description

Bibliographic Details
Main Authors:	Hekking, Pieter-Paul, Loza, Matt J., Pavlidis, Stelios, de Meulder, Bertrand, Lefaudeux, Diane, Baribaud, Fred, Auffray, Charles, Wagener, Ariane H., Brinkman, Paul, Lutter, Rene, Bansal, Aruna T., Sousa, Ana R., Bates, Steve A., Pandis, Yannis, Fleming, Louise J., Shaw, Dominique E., Fowler, Stephen J., Guo, Y., Meiser, Andrea, Sun, Kai, Corfield, Julie, Howarth, Peter H., Bel, Elisabeth H., Adcock, Ian M., Chung, Kian Fan, Djukanovic, Ratko, Sterk, Peter J.
Format:	Article
Published:	Elsevier 2018
Subjects:	Adult-onset asthma severe asthma gene set variation analysis phenotyping transcriptomics mechanisms eosinophils mast cells ILC3
Online Access:	https://eprints.nottingham.ac.uk/51853/

Similar Items

Defining the relationship between clinical and immunological features of asthma
by: Al Zahrani, Yousef
Published: (2019)

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
by: Jevnikar, Zala, et al.
Published: (2018)

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED
by: Khuo, Chih-Hsi Scott, et al.
Published: (2016)

Effects of synthetic 2, 4, 6-trihydroxy-3-geranylacetophenone upon TNF-α-induced epithelial dysfunction
by: Sim, Tee Yee
Published: (2016)

The effect of sodium on cardio-respiratory health
by: Pogson, Zara
Published: (2009)

THE IDENTIFICATION OF BIOMARKERS TO PREDICT RESPONSE TO TREATMENTS IN ASTHMA
by: Lissa, Sutherland
Published: (2019)

Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial
by: Anderson, J.R., et al.
Published: (2016)

A case study on nurse-led asthma clinic in rural Western Australia
by: Lim, David, et al.
Published: (2011)

Heparin mimetics block the activity of interleukins involved in asthma
by: Kett, Warren, et al.
Published: (2007)

A preliminary study on the collaborative use of statistical modeling in a GIS study of asthmatic morbidity / Mohammad Said Zainol, Sayed Jamaludin S. Ali and Zainal Mat Saat
by: Zainol, Mohammad Said, et al.
Published: (2005)

Standardised Andrographis paniculata Burm. Nees extracts and andrographolide prevent airway inflammation in house dust mite and diisocyanate- induced asthma models
by: Sulaiman, Ibrahim
Published: (2018)

Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma
by: Donovan, G.M., et al.
Published: (2020)

Population-based weight loss and gain do not explain trends in asthma mortality in Cuba: a prospective study from 1964 to 2014
by: Suárez-Medina, Ramon, et al.
Published: (2016)

Effects of 2,4,6-trihydroxy-3-geranyl acetophenone on growth factor-induced human bronchial smooth muscle cell proliferation in asthma
by: Yap, Hui Min
Published: (2018)

Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma
by: Hekking, Pieter-Paul, et al.
Published: (2017)

Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease
by: Baker, Jillian G., et al.
Published: (2017)

Predicting response to Azithromycin therapy in asthma
by: Slater, Mariel
Published: (2015)

What have studies of non-industrialized countries told us about the cause of allergic disease?
by: Fogarty, Andrew W.
Published: (2014)

An investigation into the association between asthma, osteoporosis, and fractures using electronic health records
by: Chalitsios, Christos
Published: (2021)

Anti-inflammatory properties of 3-(2,5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one (L31) in lung epithelial cells and on airway inflammation in a murine model of asthma
by: Rajajendram, Revathee
Published: (2014)

In vitro protective effect of zerumbone on house dust mite-induced airway epithelial barrier disruption
by: Rohhimi, Wafda
Published: (2018)

Effects of adolescent asthma education intervention on asthma control in Northwest of Libya
by: Elfeturi, Nadya Mohamed
Published: (2020)

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial
by: Hanratty, Catherine E., et al.
Published: (2018)

Parents' trust in nurses: an ethnographic study of the nurse-parent relationship within the paediatric setting
by: Chong, Germaine (Yen Ping) Lynn
Published: (2005)

Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma
by: Malkar, Aditya, et al.
Published: (2016)

Applying Marketing Mix (4Ps) to Enhance the Adherence of Asthmatics in China
by: ZHOU, HAITAO
Published: (2017)

Comparable reductions in hyperpnoea-induced bronchoconstriction and markers of airway inflammation after supplementation with 6·2 and 3·1 g/d of long-chain n-3 PUFA in adults with asthma
by: Williams, Neil C., et al.
Published: (2017)

Indoor environmental risk factors for respiratory symptoms and asthma in young children.
by: Rumchev, Krassi
Published: (2001)

Cyclization enhances function of linear anti-arthritic peptides
by: Ali, Marina, et al.
Published: (2014)

Ambient Air Pollution and its Association with the Respiratory Health of Asthmatic Primary School Children in Selected Urban, Rural and Industrial Areas in Selangor and Kuala Lumpur
by: Zakaria, Junaidah
Published: (2010)

Airway remodeling blockade with an orally active geranyl acetophenone
by: Lee, Yu Zhao
Published: (2017)

Predictors of severe exacerbations, poor asthma control, and β-agonist overuse for patients with asthma
by: Patel, Mitesh, et al.
Published: (2014)

Mathematical Models of Pro-remodelling Growth Factor Activation in Asthmatic Airways
by: Pybus, Hannah J.
Published: (2020)

Effect of smoking status on the efficacy of the SMART regimen in high risk asthma
by: Pilcher, Janine, et al.
Published: (2016)

A review of standard pharmacological therapy for adult asthma - Steps 1 to 5
by: Patel, Mitesh Dilipkumar Kantilal, et al.
Published: (2015)

Electronic monitoring of adherence to inhaled medication in asthma
by: Howard, Sam, et al.
Published: (2014)

The association between benzodiazepines and asthma exacerbation, influenza-like illness related pneumonia and mortality: population-based studies using the United Kingdom Primary care data.
by: Nakafero, Georgina
Published: (2016)

Investigating the factors affecting adherence to inhaled corticosteroids in patients with asthma using primary care data in the UK
by: Taylor, Amelia C.
Published: (2017)

A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation
by: Williams, Neil C., et al.
Published: (2016)

Exploring the impact of socio-cognitive factors on adherence to asthma medication using traditional mixed methods and machine learning
by: Ljevar, Vanja
Published: (2022)