Pathway discovery using transcriptomic profiles in adult-onset severe asthma

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

Background: Adult-onset severe asthma is characterized by highly symptomatic disease despite high-intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease is needed for the development of targeted treatments. Gene set variation analysis is a statistical tec...

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Bibliographic Details
Main Authors: Hekking, Pieter-Paul, Loza, Matt J., Pavlidis, Stelios, de Meulder, Bertrand, Lefaudeux, Diane, Baribaud, Fred, Auffray, Charles, Wagener, Ariane H., Brinkman, Paul, Lutter, Rene, Bansal, Aruna T., Sousa, Ana R., Bates, Steve A., Pandis, Yannis, Fleming, Louise J., Shaw, Dominique E., Fowler, Stephen J., Guo, Y., Meiser, Andrea, Sun, Kai, Corfield, Julie, Howarth, Peter H., Bel, Elisabeth H., Adcock, Ian M., Chung, Kian Fan, Djukanovic, Ratko, Sterk, Peter J.
Format: Article
Published: Elsevier 2018
Subjects:
Adult-onset asthma
severe asthma
gene set variation analysis
phenotyping
transcriptomics
mechanisms
eosinophils
mast cells
ILC3
Online Access:https://eprints.nottingham.ac.uk/51853/

Internet

https://eprints.nottingham.ac.uk/51853/

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