Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2

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Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2

Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although VEGF-A ligands bind to both VEGFR1 and VEGFR2, they primarily signal via VEGFR2 leading to endothelial cell proliferation,...

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Bibliographic Details
Main Authors:	Peach, Chloe, Mignone, Viviane, Arruda, Maria, Alcobia, Diana, Hill, Stephen, Kilpatrick, Laura, Woolard, Jeanette
Format:	Article
Published:	MDPI 2018
Subjects:	angiogenesis; endothelial cells; blood vessel; splicing; receptor tyrosine kinase inhibitors
Online Access:	https://eprints.nottingham.ac.uk/51835/

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