Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although VEGF-A ligands bind to both VEGFR1 and VEGFR2, they primarily signal via VEGFR2 leading to endothelial cell proliferation,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Published: |
MDPI
2018
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/51835/ |