Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation

Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation

Cyclooxygenase-2 (COX-2), with its main antifibrotic metabolite PGE, is regarded as an antifibrotic gene. Repressed COX-2 expression and deficient PGE have been shown to contribute to the activation of lung fibroblasts and excessive deposition of collagen in pulmonary fibrosis. We have previously de...

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Bibliographic Details
Main Authors: Pasini, Alice, Brand, Oliver J., Jenkins, Gisli, Knox, Alan J., Pang, Linhua
Format: Article
Published: Elsevier 2018
Subjects:
Pulmonary fibrosis ; Cyclooxygenase 2 (COX-2) ; Post-transcriptional regulation ; epigenetics ; Histone deacetylase inhibitor ; Transforming growth factor β1 (TGF-β1)
Online Access:https://eprints.nottingham.ac.uk/51701/

Internet

https://eprints.nottingham.ac.uk/51701/

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