Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations
The enantioselective nickel-catalyzed desymmetrization of allenyl cyclohexa-2,5-dienones by reaction with arylboronic acids is described. Nickel-catalyzed arylation of the allene gives allylnickel species, which undergo cyclization by 1,4allylation to produce hexahydroindol-5-ones and hexahydrofuran...
| Main Authors: | , , , |
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| Format: | Article |
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Royal Society of Chemistry
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51692/ |
| _version_ | 1848798552921210880 |
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| author | Nguyen, Thi Le Nhon Incerti-Pradillos, Celia A. Lewis, William Lam, Hon Wai |
| author_facet | Nguyen, Thi Le Nhon Incerti-Pradillos, Celia A. Lewis, William Lam, Hon Wai |
| author_sort | Nguyen, Thi Le Nhon |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The enantioselective nickel-catalyzed desymmetrization of allenyl cyclohexa-2,5-dienones by reaction with arylboronic acids is described. Nickel-catalyzed arylation of the allene gives allylnickel species, which undergo cyclization by 1,4allylation to produce hexahydroindol-5-ones and hexahydrofuran-5-ones with three contiguous stereocenters in high diastereo- and enantioselectivities. |
| first_indexed | 2025-11-14T20:21:36Z |
| format | Article |
| id | nottingham-51692 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:21:36Z |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-516922020-05-04T19:36:01Z https://eprints.nottingham.ac.uk/51692/ Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations Nguyen, Thi Le Nhon Incerti-Pradillos, Celia A. Lewis, William Lam, Hon Wai The enantioselective nickel-catalyzed desymmetrization of allenyl cyclohexa-2,5-dienones by reaction with arylboronic acids is described. Nickel-catalyzed arylation of the allene gives allylnickel species, which undergo cyclization by 1,4allylation to produce hexahydroindol-5-ones and hexahydrofuran-5-ones with three contiguous stereocenters in high diastereo- and enantioselectivities. Royal Society of Chemistry 2018-05-09 Article PeerReviewed Nguyen, Thi Le Nhon, Incerti-Pradillos, Celia A., Lewis, William and Lam, Hon Wai (2018) Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations. Chemical Communications . ISSN 1364-548X http://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC03204A#!divAbstract doi:10.1039/C8CC03204A doi:10.1039/C8CC03204A |
| spellingShingle | Nguyen, Thi Le Nhon Incerti-Pradillos, Celia A. Lewis, William Lam, Hon Wai Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations |
| title | Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations |
| title_full | Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations |
| title_fullStr | Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations |
| title_full_unstemmed | Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations |
| title_short | Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations |
| title_sort | enantioselective nickel-catalyzed arylative intramolecular 1,4allylations |
| url | https://eprints.nottingham.ac.uk/51692/ https://eprints.nottingham.ac.uk/51692/ https://eprints.nottingham.ac.uk/51692/ |