An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation
This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH) as a complication. Three virtual COPD...
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| Format: | Article |
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Wiley Open Access
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51531/ |
| _version_ | 1848798517745680384 |
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| author | Saffaran, Sina Wang, Wenfei Das, Anup Schmitt, Walter Becker-Pelster, Eva-Maria Hardman, Jonathan G. Weimann, Gerrit Bates, Declan G. |
| author_facet | Saffaran, Sina Wang, Wenfei Das, Anup Schmitt, Walter Becker-Pelster, Eva-Maria Hardman, Jonathan G. Weimann, Gerrit Bates, Declan G. |
| author_sort | Saffaran, Sina |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH) as a complication. Three virtual COPD patients were configured in the simulator based on clinical data. In agreement with previous clinical studies, modeling systemic application of a soluble guanylate cyclase (sGC) modulator results in reduced partial pressure of oxygen (PaO2) and increased partial pressure of carbon dioxide (PaCO2) in arterial blood, if a drug-induced reduction of pulmonary vascular resistance (PVR) equal to that observed experimentally is assumed. In contrast, for administration via dry powder inhalation (DPI), our simulations suggest that the treatment results in no deterioration in oxygenation. For patients under exercise, DPI administration lowers PH while oxygenation is improved with respect to baseline values. |
| first_indexed | 2025-11-14T20:21:02Z |
| format | Article |
| id | nottingham-51531 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:21:02Z |
| publishDate | 2018 |
| publisher | Wiley Open Access |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-515312020-05-04T19:44:52Z https://eprints.nottingham.ac.uk/51531/ An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation Saffaran, Sina Wang, Wenfei Das, Anup Schmitt, Walter Becker-Pelster, Eva-Maria Hardman, Jonathan G. Weimann, Gerrit Bates, Declan G. This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH) as a complication. Three virtual COPD patients were configured in the simulator based on clinical data. In agreement with previous clinical studies, modeling systemic application of a soluble guanylate cyclase (sGC) modulator results in reduced partial pressure of oxygen (PaO2) and increased partial pressure of carbon dioxide (PaCO2) in arterial blood, if a drug-induced reduction of pulmonary vascular resistance (PVR) equal to that observed experimentally is assumed. In contrast, for administration via dry powder inhalation (DPI), our simulations suggest that the treatment results in no deterioration in oxygenation. For patients under exercise, DPI administration lowers PH while oxygenation is improved with respect to baseline values. Wiley Open Access 2018-07-02 Article PeerReviewed Saffaran, Sina, Wang, Wenfei, Das, Anup, Schmitt, Walter, Becker-Pelster, Eva-Maria, Hardman, Jonathan G., Weimann, Gerrit and Bates, Declan G. (2018) An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation. CPT: Pharmacometrics & Systems Pharmacology . ISSN 2163-8306 pulmonary hypertension chronic obstructive pulmonary disease soluble guanylate cyclase modulators computer simulation https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/psp4.12308 doi:10.1002/psp4.12308 doi:10.1002/psp4.12308 |
| spellingShingle | pulmonary hypertension chronic obstructive pulmonary disease soluble guanylate cyclase modulators computer simulation Saffaran, Sina Wang, Wenfei Das, Anup Schmitt, Walter Becker-Pelster, Eva-Maria Hardman, Jonathan G. Weimann, Gerrit Bates, Declan G. An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation |
| title | An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation |
| title_full | An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation |
| title_fullStr | An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation |
| title_full_unstemmed | An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation |
| title_short | An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation |
| title_sort | inhaled sgc modulator can lower ph in copd patients without deteriorating oxygenation |
| topic | pulmonary hypertension chronic obstructive pulmonary disease soluble guanylate cyclase modulators computer simulation |
| url | https://eprints.nottingham.ac.uk/51531/ https://eprints.nottingham.ac.uk/51531/ https://eprints.nottingham.ac.uk/51531/ |