Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

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Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

Multidrug binding and transport by the ATP binding cassette transporter ABCG2 is a factor in the clinical resistance to chemotherapy in leukaemia, and a contributory factor to the pharmacokinetic profiles of many other prescribed drugs. Despite its importance, the structural basis of multidrug trans...

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Bibliographic Details
Main Authors:	Cox, Megan H., Kapoor, Parth, Briggs, Deborah A., Kerr, Ian D.
Format:	Article
Published:	Portland Press 2018
Subjects:	ATP binding cassette; BCRP; ABCG2; Pharmacology; Specificity; Flow cytometry; Structure; Docking; Binding pocket; Asymmetry
Online Access:	https://eprints.nottingham.ac.uk/51454/

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