Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets
Multidrug binding and transport by the ATP binding cassette transporter ABCG2 is a factor in the clinical resistance to chemotherapy in leukaemia, and a contributory factor to the pharmacokinetic profiles of many other prescribed drugs. Despite its importance, the structural basis of multidrug trans...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Portland Press
2018
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/51454/ |