VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis

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VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis

Chronic pain can develop in response to conditions such as inflammatory arthritis. The central mechanisms underlying the development and maintenance of chronic pain in humans are not well elucidated although there is evidence for a role of microglia and astrocytes. However in pre-clinical models of...

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Bibliographic Details
Main Authors:	Beazley-Long, Nicholas, Moss, Catherine Elizabeth, Ashby, William Robert, Bestall, Samuel Marcus, Almahasneh, Fatimah, Durrant, Alexandra Margaret, Benest, Andrew Vaughan, Blackley, Zoe, Ballmer-Hofer, Kurt, Hirashima, Masanori, Hulse, Richard Phillip, Bates, David Owen, Donaldson, Lucy Frances
Format:	Article
Language:	English
Published:	Elsevier 2018
Subjects:	Inflammatory pain; Rheumatoid arthritis; Chronic pain; Mechanical allodynia; VEGFR2; Glio-vascular activation; ICAM-1; CD11b; Microglia mono-arthritis
Online Access:	https://eprints.nottingham.ac.uk/51439/

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