Hippocampal TET1 and TET2 expression and DNA hydroxymethylation are affected by physical exercise in aged mice

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Hippocampal TET1 and TET2 expression and DNA hydroxymethylation are affected by physical exercise in aged mice

The function of 5-hydroxymethylcytosine (5hmC) is poorly understood. 5hmC is an epigenetic modification of DNA, resulting from the oxidation of 5-methylcytosine (5mC) by the Fe2+, and 2-oxoglutarate-dependent, 10–11 translocation methylcytosine dioxygenases (TET1, TET2, and TET3). Recent evidence su...

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Bibliographic Details
Main Authors:	Jessop, Peter, Toledo-Rodriguez, Maria
Format:	Article
Language:	English
Published:	Frontiers Media 2018
Subjects:	TET1; TET2; 5hmC; Exercise; Aging; Hippocampus
Online Access:	https://eprints.nottingham.ac.uk/51371/

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