To boil an egg: substrate binding affects critical stability in thermal unfolding of proteins
Thermal unfolding of proteins is used extensively in screening of drug candidates because molecular interactions with ligands and substrates affect strongly protein stability, transition temperature, and cooperativity. We use synchrotron radiation circular dichroism to monitor the thermal evolution...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
American Chemical Society
2018
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| Online Access: | https://eprints.nottingham.ac.uk/50690/ |