Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia

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Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia

Bacterial septicaemia is a major cause of mortality, but its pathogenesis remains poorly understood. In experimental pneumococcal murine intravenous infection, an initial reduction of bacteria in the blood is followed hours later by a fatal septicaemia. These events represent a population-bottleneck...

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Bibliographic Details
Main Authors:	Ercoli, Giuseppe, Fernandes, Vitor E., Chung, Wen Y., Wanford, Joseph J., Thomson, Sarah, Bayliss, Christopher D., Straatman, Kornelis, Crocker, Paul R., Dennison, Ashley, Martinez-Pomares, Luisa, Andrew, Peter W., Moxon, E. Richard, Oggioni, Marco R.
Format:	Article
Published:	Nature Publishing Group 2018
Online Access:	https://eprints.nottingham.ac.uk/50621/

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