Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

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Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease of the lungs that is currently the fourth leading cause of death worldwide. Genetic factors account for only a small amount of COPD risk, but epigenetic mechanisms, including DNA methylation, have the potential to me...

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Bibliographic Details
Main Authors:	Clifford, Rachel L., Fishbane, Nick, Patel, Jamie, MacIsaac, Julia L., McEwen, Lisa M., Fisher, Andrew J., Brandsma, Corry-Anke, Nair, Parameswaran, Kobor, Michael S., Hackett, Tillie-Louise, Knox, Alan J.
Format:	Article
Language:	English
Published:	BioMed Central 2018
Subjects:	DNA methylation Fibroblasts COPD Airway Parenchyma
Online Access:	https://eprints.nottingham.ac.uk/50529/

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