Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease of the lungs that is currently the fourth leading cause of death worldwide. Genetic factors account for only a small amount of COPD risk, but epigenetic mechanisms, including DNA methylation, have the potential to me...

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Bibliographic Details
Main Authors: Clifford, Rachel L., Fishbane, Nick, Patel, Jamie, MacIsaac, Julia L., McEwen, Lisa M., Fisher, Andrew J., Brandsma, Corry-Anke, Nair, Parameswaran, Kobor, Michael S., Hackett, Tillie-Louise, Knox, Alan J.
Format: Article
Language:English
Published: BioMed Central 2018
Subjects:
DNA methylation
Fibroblasts
COPD
Airway
Parenchyma
Online Access:https://eprints.nottingham.ac.uk/50529/

Internet

https://eprints.nottingham.ac.uk/50529/

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