PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism

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PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism

Pseudomonas aeruginosa produces a number of alkylquinolone-type secondary metabolites best known for their antimicrobial effects and involvement in cell-cell communication. In the alkylquinolone biosynthetic pathway, the β-ketoacyl-(acyl carrier protein) synthase III (FabH)-like enzyme PqsBC catalyz...

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Bibliographic Details
Main Authors:	Drees, Steffen Lorenz, Li, Chan, Prasetya, Fajar, Saleem, Muhammad, Dreveny, Ingrid, Williams, Paul, Hennecke, Ulrich, Emsley, Jonas, Fetzner, Susanne
Format:	Article
Published:	American Society for Biochemistry and Molecular Biology 2016
Online Access:	https://eprints.nottingham.ac.uk/50477/

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