PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism
Pseudomonas aeruginosa produces a number of alkylquinolone-type secondary metabolites best known for their antimicrobial effects and involvement in cell-cell communication. In the alkylquinolone biosynthetic pathway, the β-ketoacyl-(acyl carrier protein) synthase III (FabH)-like enzyme PqsBC catalyz...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Published: |
American Society for Biochemistry and Molecular Biology
2016
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| Online Access: | https://eprints.nottingham.ac.uk/50477/ |