Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)
Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of hypoxia and hyperoxia in the development and...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Published: |
BioMed Central
2018
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/50178/ |
| _version_ | 1848798176383860736 |
|---|---|
| author | Barratt, Shaney L. Blythe, Thomas Ourradi, Khadija Jarrett, Caroline Welsh, Gavin I. Bates, David O. Millar, Ann B. |
| author_facet | Barratt, Shaney L. Blythe, Thomas Ourradi, Khadija Jarrett, Caroline Welsh, Gavin I. Bates, David O. Millar, Ann B. |
| author_sort | Barratt, Shaney L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of hypoxia and hyperoxia in the development and progression of IPF has not been explored. In normal lung (NF) and IPF-derived fibroblasts (FF) VEGF-Aa protein expression was upregulated by hypoxia, mediated through activation of VEGF-Aa gene transcription. VEGF-A receptors and co-receptors were differentially expressed by hypoxia and hyperoxia. Our data supports a potential role for hypoxia, hyperoxia and VEGF-Aa isoforms as drivers of fibrogenesis. |
| first_indexed | 2025-11-14T20:15:36Z |
| format | Article |
| id | nottingham-50178 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:15:36Z |
| publishDate | 2018 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-501782020-05-04T19:26:43Z https://eprints.nottingham.ac.uk/50178/ Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF) Barratt, Shaney L. Blythe, Thomas Ourradi, Khadija Jarrett, Caroline Welsh, Gavin I. Bates, David O. Millar, Ann B. Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of hypoxia and hyperoxia in the development and progression of IPF has not been explored. In normal lung (NF) and IPF-derived fibroblasts (FF) VEGF-Aa protein expression was upregulated by hypoxia, mediated through activation of VEGF-Aa gene transcription. VEGF-A receptors and co-receptors were differentially expressed by hypoxia and hyperoxia. Our data supports a potential role for hypoxia, hyperoxia and VEGF-Aa isoforms as drivers of fibrogenesis. BioMed Central 2018-01-15 Article PeerReviewed Barratt, Shaney L., Blythe, Thomas, Ourradi, Khadija, Jarrett, Caroline, Welsh, Gavin I., Bates, David O. and Millar, Ann B. (2018) Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF). Respiratory Research, 19 . p. 9. ISSN 1465-9921 Interstitial lung disease Vascular endothelial growth factor Hypoxia Idiopathic pulmonary fibrosis https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-017-0711-x doi:10.1186/s12931-017-0711-x doi:10.1186/s12931-017-0711-x |
| spellingShingle | Interstitial lung disease Vascular endothelial growth factor Hypoxia Idiopathic pulmonary fibrosis Barratt, Shaney L. Blythe, Thomas Ourradi, Khadija Jarrett, Caroline Welsh, Gavin I. Bates, David O. Millar, Ann B. Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF) |
| title | Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF) |
| title_full | Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF) |
| title_fullStr | Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF) |
| title_full_unstemmed | Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF) |
| title_short | Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF) |
| title_sort | effects of hypoxia and hyperoxia on the differential expression of vegf-a isoforms and receptors in idiopathic pulmonary fibrosis (ipf) |
| topic | Interstitial lung disease Vascular endothelial growth factor Hypoxia Idiopathic pulmonary fibrosis |
| url | https://eprints.nottingham.ac.uk/50178/ https://eprints.nottingham.ac.uk/50178/ https://eprints.nottingham.ac.uk/50178/ |