Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells

Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells

5-Methylcytosine (5mC) is an epigenetic modification involved in regulation of gene activity during differentiation. Tet dioxygenases oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Both 5fC and 5caC can be excised from DNA by thymine-DNA glycosy...

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Main Authors: Wheldon, Lee M., Abakir, Abdulkadir, Ferjentsik, Zoltan, Dudnakova, Tatiana, Strohbuecker, Stephanie, Christie, Denise, Dai, Nan, Guan, Shengxi, Foster, Jeremy M., Corrêa, Ivan R, Loose, Matthew, Dixon, James E., Sottile, Virginie, Johnson, Andrew D., Ruzov, Alexey
Format: Article
Published: Elsevier 2014
Online Access:https://eprints.nottingham.ac.uk/49914/

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https://eprints.nottingham.ac.uk/49914/

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